The Biomolecules and Spectroscopy team performs structural studies of biomolecules, using gas phase physico-chemical technics. The goals of these studies are the understanding of the biomolecules structure-function link, the characterization of induced fit recognition mechanisms or the characterization of ionizing radiations damages induced on living molecular bricks. In addition to collaborative experiments on state-of-the art experimental apparatus (infrared multi photon dissociation experiments with free electron lasers, ion beams irradiation at GANIL), the team is developing a very new laser induced liquid bead ion desorption source : liquid micro droplets, containing the biomolecules of interest, are laser ablated directly under vacuum. This innovative source, which is unique in France, should allow to benefit from the gas phase advantages (stoichiometry control, ions manipulation and trapping) while preserving the biomolecules native structure.In parallel, quantum chemistry calculations are performed on the High Performance Computing center of the Sorbonne Paris Nord university, in order to interpret the experimental spectra.

This Master Internship will fall within these thematics, with the possibility to shift towards experimental development (optimization of the desorption source and its coupling with an irradiation platform for radiation damages studies) or towards structural studies of biomolecules (molecular cages for drugs trapping and vectorization, radiosensitizers) by the combination of spectroscopic experiments with quantum chemistry calculations.