Research Teams  | Biomolecules and spectroscopy
Page modified Thursday, March 10, 2011

Our team is interested in providing an innovative approach to the study of pharmaceutical drug-receptor interactions leading to the intimate relationship between drug activity and structure. The characterization and modeling of these weak intra- or inter-molecular interactions are very important for understanding many processes in solution chemistry and, even more, in molecular biology, e.g. molecular recognition between biomolecules. To that end, we perform IR spectroscopy of neutral isomer-selected or ionic mass-selected systems and elementary compounds (nucleic acid bases, amino acids, peptides, drugs) and their non-covalent complexes in the gas-phase for which structural assignment is done through comparison with high-level quantum chemistry calculations.


IRMPD spectrum of the RGD tripeptide recorded at CLIO. The specific loop structure of the RGD sequence found in large protein (dendroaspin) is retained in the gas phase

Calculated structure in gas phase of the vancomycin antibiotics with cell-wall peptide analogue


Our team is interested in providing an innovative approach to the study of pharmaceutical drug-receptor interactions leading to the intimate relationship between drug activity and structure. The characterization and modeling of these weak intra- or inter-molecular interactions are very important for understanding many processes in solution chemistry and, even more, in molecular biology, e.g. molecular recognition between biomolecules. To that end, we perform IR spectroscopy of neutral isomer-selected or ionic mass-selected systems and elementary compounds (nucleic acid bases, amino acids, peptides, drugs) and their non-covalent complexes in the gas-phase for which structural assignment is done through comparison with high-level quantum chemistry calculations.


IRMPD spectra of the human telomeric sequence TTAGGG  forming Guanine quadruplex obtained at the free electron laser CLIO

Picture of a new expérimental device




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